Endocrine Abstracts

IntroductionRecent published studies suggest that the anatomical location of the thyroid nodule may be associated with different risks of malignancy. However, the results are still sparce and little consensual.AimTo evaluate the frequency of nodules on different locations of the thyroid gland and to determine whether their location correlates with different malignancy risks.Methods<...

*These authors contributed equally to this workIntroductionThe prevalence of obesity has risen dramatically worldwide in the last three decades. Due to this obesity pandemic, a growing demand for weight-loss drugs has emerged. The increased use of these drugs has consequently lead to an increase in the report of adverse reactions.Case reportA 45-year-old woman with past medical history ...

IntroductionRadioiodine whole-body scintigraphy plays an important role in the follow-up of patients with differentiated thyroid carcinoma (DTC), as it is highly accurate in detecting thyroid residues and recurrent disease. Unusual 131-iodine uptake outside the thyroid bed and areas of physiological uptake is strongly suggestive of distant metastasis. However, uncommon uptake may occur and lead to diagnostic errors.Case report<...

Objective: Currently, data about the molecular profile of multifocal papillary thyroid cancer (PTC) are still controversial. The aim of this study was to fully characterize by NGS the molecular profile of different histological variants in patients affected by multifocal PTCs.Methods: for this purpose, 12 multifocal PTC patients have been studied based to the following inclusion criteria: 1) a minimum of two tumors foci per patient with at least two diff...

Background: Chronic pancreatitis (CP) is the most frequent cause of diabetes of the exocrine pancreas (DEP). Although the specific alterations of DEP are not completely understood, individuals with DEP are considered affected by pancreatic endocrine insufficiency and treated with insulin. To investigate the functional alterations of DEP, we evaluated differences in glucose metabolism in patients with and without CP, classified according to their glucose tolerance (NGT, IGT, DM...

Background: Immunotherapy is currently being explored in many tumour types with encouraging results, but has not yet been evaluated in neuroendocrine tumours (NET). Our aim is to characterise the immune landscape of NET and determine which immune-modulatory pathways control the tumour infiltrating lymphocytes (TILs) in order to develop a rational approach for immunotherapy in this tumour type.Methods: Peripheral blood and fresh tissue was obtained from c...

Background: PCBs are persistent organic pollutants, able to affect thyroid function (endocrine disruptors) and promote inflammation through multiple mechanisms. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor able to bind dioxins and dioxin-like pollutants including PCBs, play a key role in xenobiotic response, by up-regulating specific responsive genes, the so-called “AhR gene battery”, including cytochrome P450 1A1 (CYP1A1) and Nuclear ...

Background: The COVID-19 outbreak in Italy forced the health system to cancel all non-urgent outpatient activities, to avoid further spreading of the disease inside the healthcare facilities. At our institution, for cancer patients the hospital allowed treatments and consultations: the medical team, however, identified patients whose procedures could be postponed. Even after May 2020, the capacity for non-urgent thyroid surgeries was reduced. These events enhanced our efforts ...

Introduction: DM 1 is proposed as a condition of accelerated muscle aging and mitochondrial dysfunction as a common link regulating muscle deterioration in aging and DM 1. Loss of muscle mass is associated with insulin resistance, metabolic syndrome and cardiovascular complications.Objectives: To analyze body composition and metabolic variables related to insulin resistance in overweight/obese patients with DM1.Material and MethodsObservational, cross-se...

Introduction: Thyroid nodules represent a common cause of specialist consultation, with a risk of malignancy of 4-15%. The most widely used cytopathological method for diagnosing thyroid cancer is fine-needle aspiration biopsy (FNAB) of thyroid nodules and the use of the Bethesda system (BS) for cytopathological reporting. We conducted the present study to report our experience using the BS, and to compare the results obtained with this system with the final histopathological ...